WebMay 25, 2011 · Using the trifluoromethylation reagent iodotrifluoromethane, the chiral organocatalyst 28, the iridium catalyst 29, and light from a fluorescent light bulb, aldehydes were transformed into the ... WebJun 22, 2024 · A para -selective C−H trifluoromethylation of benzamide derivatives was developed that makes use of iminium intermediates. The iminium species, formed in situ from Tf 2 O, pyridine and amides, feature greatly enhanced reactivity at the para -position towards radical-type nucleophilic C−H trifluoromethylation. Abstract
Recent advances in the trifluoromethylation methodology …
WebNov 14, 2024 · The resulting chiral difluoroalkylated alkynes can serve as versatile building blocks for the diversity-oriented synthesis. As shown in Scheme 3 A ( Figures S225–S247), Sonogashira reaction of 3d with heteroaryl iodides and reduction of the carbonyl group with NaBH4 proceeded smoothly. WebElectrochemical tandem trifluoromethylation of allylamines/formal (3 + 2)-cycloaddition for the rapid access to CF 3 -containing imidazolines and oxazolidines. Organic Chemistry Frontiers 2024, 8 (2) , 288-296. gran living proff
The Bifunctional Silyl Reagent Me2(CH2Cl)SiCF3 Enables Highly ...
WebDec 13, 2024 · α -Trifluoromethyl cycloheptanones containing the C (sp 3 )−CF 3 bond on the chiral centers were accessed through a highly stereoselective Sc III /chiral bisoxazoline-catalyzed homologation reaction of cyclic ketones with CF 3 CHN 2 as the trifluoromethylation reagent. WebMay 25, 2011 · Using the trifluoromethylation reagent iodotrifluoromethane, the chiral organocatalyst 28, the iridium catalyst 29, and light from a fluorescent light bulb, … WebThe trifluoromethyl group can be regarded as a classical isostere of nonpolar groups in proteinogenic α-amino acid side chains, namely, CH 3, SCH 3, CH (CH 3) 2, and CH 2 CH 3. Therefore, one can design a number of rigid trifluoromethyl-substituted amino acids to use as CF 3 -labels. gran lattissima milk frother replacement