Bisdiphosphoinositol tetrakisphosphate
WebMar 16, 1998 · Bis-diphosphoinositol tetrakisphosphate ([PP]2-InsP4 or 'InsP8') is a 'high-energy' inositol phosphate; we report that its metabolism is receptor-regulated in DDT1 MF-2 smooth muscle cells. This conclusion arose by pursuing the mechanism by which F- decreased cellular levels of [PP]2-InsP4 up to 70%. A similar effect was induced by … WebExpression of human VIP1 in HEK293T cells engineered to produce high levels of IP 7 results in dramatic increases in bisdiphosphoinositol tetrakisphosphate (PP 2-IP 4 or IP 8). Northern blot analysis indicates that human VIP1 is expressed in a variety of tissues and is enriched in skeletal muscle, heart, and brain. The subcellular distribution ...
Bisdiphosphoinositol tetrakisphosphate
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WebDescription: Homo sapiens nudix hydrolase 3 (NUDT3), mRNA. (from RefSeq NM_006703) RefSeq Summary (NM_006703): NUDT3 belongs to the MutT, or Nudix, protein family. Nudix proteins act as homeostatic checkpoints at important stages in nucleoside phosphate metabolic pathways, guarding against elevated levels of potentially dangerous … WebSafrany et al. (1998) characterized rat Nudt3 and found that it cleaved the beta-phosphate from diphosphate groups in diphosphoinositol pentakisphosphate (PP-InsP5) and bisdiphosphoinositol tetrakisphosphate ((PP)2-InsP4). Inositol hexakisphosphate was not a substrate, but it inhibited metabolism of both (PP)2-InsP4 and PP-InsP5. …
WebFunction. Cleaves a beta-phosphate from the diphosphate groups in PP-InsP5 (diphosphoinositol pentakisphosphate), PP-InsP4 and [PP]2-InsP4 (bisdiphosphoinositol tetrakisphosphate), suggesting that it may play a role in signal transduction. Also able to catalyze the hydrolysis of dinucleoside oligophosphate Ap6A, but not Ap5A.
WebThe crystal structure of the headgroup inositol 1,3,4,5-tetrakisphosphate Ins(1,3,4,5)P4-PKB complex facilitates... View Characterisation of a bis(5′-nucleosyl)-tetraphosphatase (asymmetrical ... WebNov 1, 2004 · PDF Evidence has accumulated that inositol pyrophosphates (diphosphoinositol pentakisphosphate (PP-InsP5) and bisdiphosphoinositol …
WebJan 23, 2007 · Also cleaves a beta-phosphate from the diphosphate groups in PP-InsP5 (diphosphoinositol pentakisphosphate) and [PP]2-InsP4 (bisdiphosphoinositol tetrakisphosphate) (PubMed:10085096, PubMed:10419486). Also has endopolyphosphatase activity (PubMed:31175919). 3 publications
WebPhosphatidylinositol 4,5-bisphosphate (PI4,5P(2)) is a key lipid signaling molecule that regulates a vast array of biological activities. PI4,5P(2) can act directly as a messenger … flowchart of digestion and absorption of foodWebMar 16, 1998 · Bis-diphosphoinositol tetrakisphosphate ([PP]2-InsP4 or 'InsP8') is a 'high-energy' inositol phosphate; we report that its metabolism is receptor-regulated in DDT1 … greek freak seasoning mixWebExpression of human VIP1 in HEK293T cells engineered to produce high levels of IP7 results in dramatic increases in bisdiphosphoinositol tetrakisphosphate (PP2-IP4 or IP8). Northern blot analysis indicates that human VIP1 is expressed in a variety of tissues and is enriched in skeletal muscle, heart, and brain. The subcellular distribution of ... flowchart of employee management systemWebJun 15, 2013 · Key words: bisdiphosphoinositol tetrakisphosphate (IP 8), 5-diphosphoinositol pentakisphosphate (IP 7), inositol hexaki-sphosphate (IP 6) kinase (IP6K), inositol phosphate, metabolism, flow chart of electricityWebInactivation is initiated either by dephosphorylation to inositol 1,4-bisphosphate (Fig. 4.7) or by an initial phosphorylation to a tetrakisphosphate form that is dephosphorylated by a … flowchart of e commerce websiteWeb) and bisdiphosphoinositol tetrakisphosphate (IP 8 or (PP) 2-IP 4). Likewise IP 5 is the precursor of additional inositol pyrophosphates such diphosphoinositol tetrakisphosphate (PP-IP 4) and other less characterized pyrophosphate-containing molecules that retain an unphosphorylated ring hydroxyl [2,3]. Recently, an flowchart of design processWebWe provide evidence that Plc1p, Arg82p, Kcs1p, and Adk1p negatively regulate the PHO pathway independently of the intracellular orthophosphate levels, raising the possibility that diphosphoinositol tetrakisphosphate … flow chart of erp system